Male Contraceptive pills Has Been Found 99 Percent Efficient On Mice: Study

Male Contraceptive pills

On the 16th of October, 1916 on the 16th of October 1916, a nurse called Margaret Sanger opened the first birth control clinic in America. The next day, police raided the clinic and closed it.

The rapid re-opening of Sanger’s clinic is testimony to how contraceptives for females have been controversial, scrutinized and even not accessible for more than 100 years. Since there has been no controversy over male condoms, one can only wonder how the discourse regarding contraception for women’s reproduction system that typically is available in the form of a hormonal pill could be different if males were consumers.

Today, birth control’s history may be about to enter a new phase because a team of researchers announced in the last week they’ve come up with an oral contraceptive suitable for those with male reproductive organs. The product has demonstrated astonishing results in tests conducted on mice.

The study presented at the annual meeting of the American Chemical Society revealed that a male contraceptive Pills without hormones proved effective in preventing the occurrence of pregnancies in male mice, significantly, without apparent adverse consequences. Notably, the contraceptive, known as”YCT529″ (which refers to the brand name given to the substance), created temporarily impervious male mice. During the test, male mice were administered the pill every day. Within 4 weeks, Who discovered the pill that was 99 per cent effective in stopping the development of pregnancy in female mice. Furthermore, four weeks after Who stopped male mice receiving YCT529 and YCT529; they could immunize female mice once more.

This study was carried out on mice, not on humans. However, the scientists are hopeful that this could result in a contraceptive pill for men in the not too distant future.

“These are mice, they’re not human, but the results were highly hopeful,” said one of the scientists involved in the research, Gunda Georg, an associate director at the University of Minnesota’s College of Pharmacy, in an announcement to the media. “[Andthere are no side consequences whatsoever that are very wonderful news.”

This isn’t the first instance male contraceptives have been advertised and tried. However, prior studies haven’t progressed further due to side consequences. A case in point is a study of a promising male hormonal contraceptive in 2016 that was forced to be stopped due to adverse negative effects, such as severe depression and acne; specifically, adverse effects commonly observed when using hormonal contraceptives for women.

The main thing to note about YCT529 is it’s not a hormonal contraceptive. This means it doesn’t attack testosterone, which is the testosterone-based male hormone produced by the testes. Instead, female birth control is achieved with hormones to stop Ovulation.

Researchers Georg and Md Abdullah Al Noman, an undergraduate student of the University of Minnesota, instead focused on a protein known as ” retinoic acid receptor alpha.” Through targeting the protein, researchers developed a compound called YCT529 that prevents it from interfering with other receptors that produce Vitamin A. Previous research has revealed that mice deficient in Vitamin A can’t reproduce.

“Mice that don’t have this receptor develop infertility, and in other ways, they’re healthy,” Georg said. “And this is why it’s so important that you eliminate the target and get the desired result; however, the mice are still healthy and viable, so they chose this specific area of study.”

Human trials for the drug are anticipated to start in 2022 after receiving FDA approval. If everything goes as planned, Georg said after several stages of clinical trials, such drugs could be on the market within five years.

“Usually, it takes longer, but if everything is working out as it should, maybe we’ll be able to be more efficient,” Georg told me.

Georg said it’s crucial to understand that this effort is about “reproductive choices for everyone.”

“I believe that this is very crucial,” Georg said. “The female has many options to control their fertility; however, it’s very restricted for males. If we could expand the options for couples and men, it could be very beneficial.”

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